RQ-00201894: A motilin receptor agonist causing long-lasting facilitation of human gastric cholinergically-mediated contractions

RQ-00201894: A motilin receptor agonist causing long-lasting facilitation of human gastric cholinergically-mediated contractions

The aim was to characterise RQ-00201894, a novel non-macrolide motilin agonist, using human recombinant receptors and then investigate its ability to facilitate cholinergic activity in human stomach. A reporter gene assay assessed motilin receptor function. Selectivity of action was determined using...

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Bibliographic Details
Main Authors: John Broad, Nobuyuki Takahashi, Masaomi Tajimi, Masaki Sudo, Adam Góralczyk, Umesh Parampalli, Kesava Mannur, Toshinori Yamamoto, Gareth J. Sanger
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Journal of Pharmacological Sciences
Subjects:
Motilin
RQ-00201894
Human stomach
Cholinergic activity
Gastroparesis
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315002261

Internet

http://www.sciencedirect.com/science/article/pii/S1347861315002261

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