Stringent Nucleotide Recognition by the Ribosome at the Middle Codon Position

Stringent Nucleotide Recognition by the Ribosome at the Middle Codon Position

Accurate translation of the genetic code depends on mRNA:tRNA codon:anticodon base pairing. Here we exploit an emissive, isosteric adenosine surrogate that allows direct measurement of the kinetics of codon:anticodon University of California base formation during protein synthesis. Our results sugge...

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Bibliographic Details
Main Authors: Wei Liu, Dongwon Shin, Martin Ng, Karissa Y. Sanbonmatsu, Yitzhak Tor, Barry S. Cooperman
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Molecules
Subjects:
fluorescent mRNA
mRNA:tRNA base pairing
kinetic mechanism
steric constraint
atomic mutagenesis
Online Access:https://www.mdpi.com/1420-3049/22/9/1427

Internet

https://www.mdpi.com/1420-3049/22/9/1427

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