Case Report: Association of a Variant of Unknown Significance in the FIG4 Gene With Frontotemporal Dementia and Slowly Progressing Motoneuron Disease: A Case Report Depicting Common Challenges in Clinical and Genetic Diagnostics of Rare Neuropsychiatric and Neurologic Disorders

Case Report: Association of a Variant of Unknown Significance in the FIG4 Gene With Frontotemporal Dementia and Slowly Progressing Motoneuron Disease: A Case Report Depicting Common Challenges in Clinical and Genetic Diagnostics of Rare Neuropsychiatric and Neurologic Disorders

BackgroundModern genetics have in many ways revolutionized clinical routine and have, for instance, shown that formerly distinct disease entities relate to common pathogenic mutations. One such example is the connection between dementia and amyotrophic lateral sclerosis (ALS) in a continuous disease...

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Bibliographic Details
Main Authors: Caroline Gertrud Bergner, Christiane Michaela Neuhofer, Claudia Funke, Saskia Biskup, Philipp von Gottberg, Claudia Bartels, Jan Christoph Koch, Katrin Radenbach
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Neuroscience
Subjects:
amyotrophic lateral sclerosis
dementia
FIG4
neurodegeneration
genetics
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.559670/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2020.559670/full

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