Mesenchymal Cells Support the Oncogenicity and Therapeutic Response of the Hedgehog Pathway in Triple-Negative Breast Cancer

Mesenchymal Cells Support the Oncogenicity and Therapeutic Response of the Hedgehog Pathway in Triple-Negative Breast Cancer

The paracrine interaction between tumor cells and adjacent stroma has been associated with the oncogenic activity of the Hedgehog (Hh) pathway in triple-negative breast tumors. The present study developed a model of paracrine Hh signaling and examined the impact of mesenchymal cell sources and cultu...

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Bibliographic Details
Main Authors: Ana M. Reyes-Ramos, Karla P. Ramos-Cruz, Nelson J. Rodríguez-Merced, Michelle M. Martínez-Montemayor, Nelson D. Franqui-Ríos, Jan P. Ríos-Grant, Andrea Flores, Gerónimo Maldonado-Martínez, Wandaliz Torres-García, Maribella Domenech
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
hedgehog signaling
triple-negative breast cancer
cafs
emt
mesenchyme
tumor microenvironment
Online Access:https://www.mdpi.com/2072-6694/11/10/1522

Internet

https://www.mdpi.com/2072-6694/11/10/1522

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