Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats

Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats

Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by selective striatal neuron loss and motor, cognitive and affective disturbances. The present study aimed to test the hypothesis of adult-onset neuron loss in striatum and frontal cortical layer V as well as alt...

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Bibliographic Details
Main Authors: Orsolya Kántor, Yasin Temel, Carsten Holzmann, Kerstin Raber, Huu-Phuc Nguyen, Chunyan Cao, Hatice Özen Türkoglu, Bart P.F. Rutten, Veerle Visser-Vandewalle, Harry W.M. Steinbusch, Arjan Blokland, Hubert Korr, Olaf Riess, Stephan von Hörsten, Christoph Schmitz
Format: Article
Language:English
Published: Elsevier 2006-06-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
Transgenic
Rat
Striatum
Cortex
Stereology
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105003499

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http://www.sciencedirect.com/science/article/pii/S0969996105003499

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