Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane

Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane

Colistin is an antibiotic of last resort, but has poor efficacy and resistance is a growing problem. Whilst it is well established that colistin disrupts the bacterial outer membrane (OM) by selectively targeting lipopolysaccharide (LPS), it was unclear how this led to bacterial killing. We discover...

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Bibliographic Details
Main Authors: Akshay Sabnis, Katheryn LH Hagart, Anna Klöckner, Michele Becce, Lindsay E Evans, R Christopher D Furniss, Despoina AI Mavridou, Ronan Murphy, Molly M Stevens, Jane C Davies, Gérald J Larrouy-Maumus, Thomas B Clarke, Andrew M Edwards
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
Polymyxin
Colistin
lipopolysaccharide
phospholipids
Pseudomonas
E. coli
Online Access:https://elifesciences.org/articles/65836

Internet

https://elifesciences.org/articles/65836

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