Normal Hematopoetic Stem and Progenitor Cells Can Exhibit Metabolic Flexibility Similar to Cancer Cells

Normal Hematopoetic Stem and Progenitor Cells Can Exhibit Metabolic Flexibility Similar to Cancer Cells

It is known that cancer stem cells (CSCs) with the largest proliferative capacity survive the anoxic and/or ischemic conditions present inside tumorous tissue. In this study we test whether normal stem cells can survive under the same conditions due to cancer cell-like metabolic adaptations. We cult...

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Bibliographic Details
Main Authors: Marija Vlaski-Lafarge, Veronique Labat, Alexandra Brandy, Alice Refeyton, Pascale Duchez, Laura Rodriguez, Nyere Gibson, Philippe Brunet de la Grange, Zoran Ivanovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
cancer stem cells
hematopoietic stem cells
metabolism
bioenergetics
mitochondrial respiration
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00713/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00713/full

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