Fertility Outcomes and Sperm-DNA Parameters in Metastatic Melanoma Survivors Receiving Vemurafenib or Dabrafenib Therapy: Case Report

Fertility Outcomes and Sperm-DNA Parameters in Metastatic Melanoma Survivors Receiving Vemurafenib or Dabrafenib Therapy: Case Report

Melanoma is a frequent neoplasm in young adult males in reproductive age, 10% of them degenerating into regional and/or distant metastases (MM). The use of BRAF inhibitors (BRAFi) vemurafenib and dabrafenib is effective in MM patients harboring BRAF V600E/K/D mutations. Despite the increased life ex...

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Bibliographic Details
Main Authors: Marco Ghezzi, Andrea Garolla, Sabina Magagna, Iva Šabovich, Massimiliano Berretta, Carlo Foresta, Luca De Toni
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Oncology
Subjects:
metastatic melanoma
BRAF inhibitors
male fertility
sperm DNA
cryopreservation
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00232/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00232/full

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