Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection.

Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection.

In most bacteria, Clp protease is a conserved, non-essential serine protease that regulates the response to various stresses. Mycobacteria, including Mycobacterium tuberculosis (Mtb) and Mycobacterium smegmatis, unlike most well studied prokaryotes, encode two ClpP homologs, ClpP1 and ClpP2, in a si...

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Bibliographic Details
Main Authors: Ravikiran M Raju, Meera Unnikrishnan, Daniel H F Rubin, Vidhya Krishnamoorthy, Olga Kandror, Tatos N Akopian, Alfred L Goldberg, Eric J Rubin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3280978?pdf=render

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http://europepmc.org/articles/PMC3280978?pdf=render

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