Transgenic expression of a T cell epitope in Strongyloides ratti reveals that helminth-specific CD4+ T cells constitute both Th2 and Treg populations.

Transgenic expression of a T cell epitope in Strongyloides ratti reveals that helminth-specific CD4+ T cells constitute both Th2 and Treg populations.

Helminths are distinct from microbial pathogens in both size and complexity, and are the likely evolutionary driving force for type 2 immunity. CD4+ helper T cells can both coordinate worm clearance and prevent immunopathology, but issues of T cell antigen specificity in the context of helminth-indu...

Full description

Bibliographic Details
Main Authors: Bonnie Douglas, Yun Wei, Xinshe Li, Annabel Ferguson, Li-Yin Hung, Christopher Pastore, Jonathan R Kurtz, James B McLachlan, Thomas J Nolan, James Lok, De'Broski R Herbert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009709

Internet

https://doi.org/10.1371/journal.ppat.1009709

Similar Items