Environmental levels and toxicological potencies of a novel mixed halogenated carbazole
The present work involves an extensive analytical and toxicological description of a recently identified mixed halogenated carbazole found in sediment samples, 1,8-dibromo-3,6-dichloro-9H-carbazole (BCCZ). Concentrations and the relative effect potency (REP) were calculated for the target BCCZ in a...
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KeAi Communications Co., Ltd.
2016-09-01
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| Series: | Emerging Contaminants |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405665016300312 |
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doaj-f66fc4f9c9a84c9ab94c3dfee05757642021-02-02T07:50:30ZengKeAi Communications Co., Ltd.Emerging Contaminants2405-66502016-09-012316617210.1016/j.emcon.2016.07.002Environmental levels and toxicological potencies of a novel mixed halogenated carbazoleMiren Pena-Abaurrea0Matthew Robson1Sri Chaudhuri2Nicole Riddell3Robert McCrindle4Brock Chittim5Robert Parette6Un-Ho Jin7Stephen Safe8David Poirier9Ralph Ruffolo10Richard Dyer11Rachael Fletcher12Paul A. Helm13Eric J. Reiner14Department of Analysis, CEPSA Research Center, Alcala de Henares, 28805, SpainDepartment of Chemistry, Brock University, St. Catharines, ON, L2S 3A1, CanadaConservation Ontario, Newmarket, ON, L3Y 2P5, CanadaWellington Laboratories Inc., Guelph, ON, N1G 3M5, CanadaWellington Laboratories Inc., Guelph, ON, N1G 3M5, CanadaWellington Laboratories Inc., Guelph, ON, N1G 3M5, CanadaMatson & Associates, Inc., State College, PA, 16801, USAVeterinary Medicine & Biomedical Sciences, Texas A&M University, Texas, TX, 77843–4461, USAVeterinary Medicine & Biomedical Sciences, Texas A&M University, Texas, TX, 77843–4461, USAOntario Ministry of the Environment and Climate Change, Toronto, ON, M9P 3V6, CanadaOntario Ministry of the Environment and Climate Change, Toronto, ON, M9P 3V6, CanadaMinistry of Northern Development and Mines, Sudbury, ON, P3E 6B5, CanadaOntario Ministry of the Environment and Climate Change, Toronto, ON, M9P 3V6, CanadaOntario Ministry of the Environment and Climate Change, Toronto, ON, M9P 3V6, CanadaDepartment of Chemistry, University of Toronto, Toronto, ON, M5S 3H6, CanadaThe present work involves an extensive analytical and toxicological description of a recently identified mixed halogenated carbazole found in sediment samples, 1,8-dibromo-3,6-dichloro-9H-carbazole (BCCZ). Concentrations and the relative effect potency (REP) were calculated for the target BCCZ in a set of stream sediments collected in 2008 in Ontario, Canada. The levels calculated for BCCZ as compared to those previously assessed for legacy persistent organic pollutants (POPs) in the same samples revealed a significant contribution of BCCZ to the total organic chemical contamination (<1%–95%; average 37%). The corresponding dioxin toxic equivalencies (TEQs) of BCCZ in the sediment extracts were estimated from experimental REP data. The experimental data presented supports the classification of this emerging halogenated chemical as a contaminant of emerging environmental concern. Although potential emission sources could not be identified, this study highlights the importance of on-going research for complete characterization of halogenated carbazoles and related compounds.http://www.sciencedirect.com/science/article/pii/S2405665016300312Halogenated carbazolesLevelsGC×GCREPTEQDioxin-likeRisk assessmentRegulation |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Miren Pena-Abaurrea Matthew Robson Sri Chaudhuri Nicole Riddell Robert McCrindle Brock Chittim Robert Parette Un-Ho Jin Stephen Safe David Poirier Ralph Ruffolo Richard Dyer Rachael Fletcher Paul A. Helm Eric J. Reiner |
| spellingShingle |
Miren Pena-Abaurrea Matthew Robson Sri Chaudhuri Nicole Riddell Robert McCrindle Brock Chittim Robert Parette Un-Ho Jin Stephen Safe David Poirier Ralph Ruffolo Richard Dyer Rachael Fletcher Paul A. Helm Eric J. Reiner Environmental levels and toxicological potencies of a novel mixed halogenated carbazole Emerging Contaminants Halogenated carbazoles Levels GC×GC REP TEQ Dioxin-like Risk assessment Regulation |
| author_facet |
Miren Pena-Abaurrea Matthew Robson Sri Chaudhuri Nicole Riddell Robert McCrindle Brock Chittim Robert Parette Un-Ho Jin Stephen Safe David Poirier Ralph Ruffolo Richard Dyer Rachael Fletcher Paul A. Helm Eric J. Reiner |
| author_sort |
Miren Pena-Abaurrea |
| title |
Environmental levels and toxicological potencies of a novel mixed halogenated carbazole |
| title_short |
Environmental levels and toxicological potencies of a novel mixed halogenated carbazole |
| title_full |
Environmental levels and toxicological potencies of a novel mixed halogenated carbazole |
| title_fullStr |
Environmental levels and toxicological potencies of a novel mixed halogenated carbazole |
| title_full_unstemmed |
Environmental levels and toxicological potencies of a novel mixed halogenated carbazole |
| title_sort |
environmental levels and toxicological potencies of a novel mixed halogenated carbazole |
| publisher |
KeAi Communications Co., Ltd. |
| series |
Emerging Contaminants |
| issn |
2405-6650 |
| publishDate |
2016-09-01 |
| description |
The present work involves an extensive analytical and toxicological description of a recently identified mixed halogenated carbazole found in sediment samples, 1,8-dibromo-3,6-dichloro-9H-carbazole (BCCZ). Concentrations and the relative effect potency (REP) were calculated for the target BCCZ in a set of stream sediments collected in 2008 in Ontario, Canada. The levels calculated for BCCZ as compared to those previously assessed for legacy persistent organic pollutants (POPs) in the same samples revealed a significant contribution of BCCZ to the total organic chemical contamination (<1%–95%; average 37%). The corresponding dioxin toxic equivalencies (TEQs) of BCCZ in the sediment extracts were estimated from experimental REP data. The experimental data presented supports the classification of this emerging halogenated chemical as a contaminant of emerging environmental concern. Although potential emission sources could not be identified, this study highlights the importance of on-going research for complete characterization of halogenated carbazoles and related compounds. |
| topic |
Halogenated carbazoles Levels GC×GC REP TEQ Dioxin-like Risk assessment Regulation |
| url |
http://www.sciencedirect.com/science/article/pii/S2405665016300312 |
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