Cytotoxic activity and apoptosis-inducing potential of di-spiropyrrolidino and di-spiropyrrolizidino oxindole andrographolide derivatives.

Cytotoxic activity and apoptosis-inducing potential of di-spiropyrrolidino and di-spiropyrrolizidino oxindole andrographolide derivatives.

Anticancer role of andrographolide is well documented. To find novel potent derivatives with improved cytotoxicity than andrographolide on cancer cells, two series of di-spiropyrrolidino- and di-spiropyrrolizidino oxindole andrographolide derivatives prepared by cyclo-addition of azomethine ylide al...

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Bibliographic Details
Main Authors: Sumit Kumar Dey, Dipayan Bose, Abhijit Hazra, Subhendu Naskar, Abhishek Nandy, Rudra Narayan Munda, Subhadip Das, Nabanita Chatterjee, Nirup Bikash Mondal, Sukdeb Banerjee, Krishna Das Saha
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3589478?pdf=render

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http://europepmc.org/articles/PMC3589478?pdf=render

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