Costs and Benefits of Mutational Robustness in RNA Viruses
The accumulation of mutations in RNA viruses is thought to facilitate rapid adaptation to changes in the environment. However, most mutations have deleterious effects on fitness, especially for viruses. Thus, tolerance to mutations should determine the nature and extent of genetic diversity that can...
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doaj-f67525316f5e4dd18ac6ec5250870b5c2020-11-24T22:11:21ZengElsevierCell Reports2211-12472014-08-01841026103610.1016/j.celrep.2014.07.011Costs and Benefits of Mutational Robustness in RNA VirusesAdi Stern0Simone Bianco1Ming Te Yeh2Caroline Wright3Kristin Butcher4Chao Tang5Rasmus Nielsen6Raul Andino7Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USADepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USADepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USADepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USADepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USACenter for Quantitative Biology, School of Life Sciences, Peking University, Beijing 100871, ChinaDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USADepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USAThe accumulation of mutations in RNA viruses is thought to facilitate rapid adaptation to changes in the environment. However, most mutations have deleterious effects on fitness, especially for viruses. Thus, tolerance to mutations should determine the nature and extent of genetic diversity that can be maintained in the population. Here, we combine population genetics theory, computer simulation, and experimental evolution to examine the advantages and disadvantages of tolerance to mutations, also known as mutational robustness. We find that mutational robustness increases neutral diversity and, as expected, can facilitate adaptation to a new environment. Surprisingly, under certain conditions, robustness may also be an impediment for viral adaptation, if a highly diverse population contains a large proportion of previously neutral mutations that are deleterious in the new environment. These findings may inform therapeutic strategies that cause extinction of otherwise robust viral populations.http://www.sciencedirect.com/science/article/pii/S2211124714005786 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Adi Stern Simone Bianco Ming Te Yeh Caroline Wright Kristin Butcher Chao Tang Rasmus Nielsen Raul Andino |
spellingShingle |
Adi Stern Simone Bianco Ming Te Yeh Caroline Wright Kristin Butcher Chao Tang Rasmus Nielsen Raul Andino Costs and Benefits of Mutational Robustness in RNA Viruses Cell Reports |
author_facet |
Adi Stern Simone Bianco Ming Te Yeh Caroline Wright Kristin Butcher Chao Tang Rasmus Nielsen Raul Andino |
author_sort |
Adi Stern |
title |
Costs and Benefits of Mutational Robustness in RNA Viruses |
title_short |
Costs and Benefits of Mutational Robustness in RNA Viruses |
title_full |
Costs and Benefits of Mutational Robustness in RNA Viruses |
title_fullStr |
Costs and Benefits of Mutational Robustness in RNA Viruses |
title_full_unstemmed |
Costs and Benefits of Mutational Robustness in RNA Viruses |
title_sort |
costs and benefits of mutational robustness in rna viruses |
publisher |
Elsevier |
series |
Cell Reports |
issn |
2211-1247 |
publishDate |
2014-08-01 |
description |
The accumulation of mutations in RNA viruses is thought to facilitate rapid adaptation to changes in the environment. However, most mutations have deleterious effects on fitness, especially for viruses. Thus, tolerance to mutations should determine the nature and extent of genetic diversity that can be maintained in the population. Here, we combine population genetics theory, computer simulation, and experimental evolution to examine the advantages and disadvantages of tolerance to mutations, also known as mutational robustness. We find that mutational robustness increases neutral diversity and, as expected, can facilitate adaptation to a new environment. Surprisingly, under certain conditions, robustness may also be an impediment for viral adaptation, if a highly diverse population contains a large proportion of previously neutral mutations that are deleterious in the new environment. These findings may inform therapeutic strategies that cause extinction of otherwise robust viral populations. |
url |
http://www.sciencedirect.com/science/article/pii/S2211124714005786 |
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