Glucocorticoids Target Ependymal Glia and Inhibit Repair of the Injured Spinal Cord

Glucocorticoids Target Ependymal Glia and Inhibit Repair of the Injured Spinal Cord

Following injury, the mammalian spinal cord forms a glial scar and fails to regenerate. In contrast, vertebrate fish spinal cord tissue regenerates significantly to restore function. Cord transection in zebrafish (Danio rerio) initially causes paralysis and neural cell death. Subsequently, ependymal...

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Bibliographic Details
Main Authors: Craig M. Nelson, Vanda A. Lennon, Han Lee, Randall G. Krug, Aichurok Kamalova, Nicolas N. Madigan, Karl J. Clark, Anthony J. Windebank, John R. Henley
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
neural regeneration
spinal cord injury
glucocorticoid signaling
Nr3c1
ependymal glia
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00056/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00056/full

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