Intra-Gene DNA Methylation Variability Is a Clinically Independent Prognostic Marker in Women's Cancers.

Intra-Gene DNA Methylation Variability Is a Clinically Independent Prognostic Marker in Women's Cancers.

We introduce a novel per-gene measure of intra-gene DNA methylation variability (IGV) based on the Illumina Infinium HumanMethylation450 platform, which is prognostic independently of well-known predictors of clinical outcome. Using IGV, we derive a robust gene-panel prognostic signature for ovarian...

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Bibliographic Details
Main Authors: Thomas E Bartlett, Allison Jones, Ellen L Goode, Brooke L Fridley, Julie M Cunningham, Els M J J Berns, Elisabeth Wik, Helga B Salvesen, Ben Davidson, Claes G Trope, Sandrina Lambrechts, Ignace Vergote, Martin Widschwendter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0143178

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https://doi.org/10.1371/journal.pone.0143178

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