Topoisomerase VI senses and exploits both DNA crossings and bends to facilitate strand passage

Topoisomerase VI senses and exploits both DNA crossings and bends to facilitate strand passage

Type II topoisomerases manage DNA supercoiling and aid chromosome segregation using a complex, ATP-dependent duplex strand passage mechanism. Type IIB topoisomerases and their homologs support both archaeal/plant viability and meiotic recombination. Topo VI, a prototypical type IIB topoisomerase, co...

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Bibliographic Details
Main Authors: Timothy J Wendorff, James M Berger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
ATP-dependent molecular machines
DNA topology
type II topoisomerases
protein-nucleic acid interactions
protein allostery
Online Access:https://elifesciences.org/articles/31724

Internet

https://elifesciences.org/articles/31724

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