ALOX5 exhibits anti-tumor and drug-sensitizing effects in MLL-rearranged leukemia

ALOX5 exhibits anti-tumor and drug-sensitizing effects in MLL-rearranged leukemia

Abstract MLL-rearranged acute myeloid leukemia (AML) remains a fatal disease with a high rate of relapse and therapeutic failure due to chemotherapy resistance. In analysis of our Affymetrix microarray profiling and chromatin immunoprecipitation (ChIP) assays, we found that ALOX5 is especially down-...

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Bibliographic Details
Main Authors: Yungui Wang, Jennifer R. Skibbe, Chao Hu, Lei Dong, Kyle Ferchen, Rui Su, Chenying Li, Hao Huang, Hengyou Weng, Huilin Huang, Xi Qin, Jie Jin, Jianjun Chen, Xi Jiang
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-01913-y

Internet

https://doi.org/10.1038/s41598-017-01913-y

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