Predicting phenotypic severity of uncertain gene variants in the RET proto-oncogene.

Predicting phenotypic severity of uncertain gene variants in the RET proto-oncogene.

Although reported gene variants in the RET oncogene have been directly associated with multiple endocrine neoplasia type 2 and hereditary medullary thyroid carcinoma, other mutations are classified as variants of uncertain significance (VUS) until the associated clinical phenotype is made clear. Cur...

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Bibliographic Details
Main Authors: David K Crockett, Stephen R Piccolo, Perry G Ridge, Rebecca L Margraf, Elaine Lyon, Marc S Williams, Joyce A Mitchell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3068179?pdf=render

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http://europepmc.org/articles/PMC3068179?pdf=render

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