Direct Amidation to Access 3-Amido-1,8-Naphthalimides Including Fluorescent Scriptaid Analogues as HDAC Inhibitors

Direct Amidation to Access 3-Amido-1,8-Naphthalimides Including Fluorescent Scriptaid Analogues as HDAC Inhibitors

Methodology to access fluorescent 3-amido-1,8-naphthalimides using direct Buchwald–Hartwig amidation is described. The protocol was successfully used to couple a number of substrates (including an alkylamide, an arylamide, a lactam and a carbamate) to 3-bromo-1,8-naphthalimide in good yield. To furt...

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Bibliographic Details
Main Authors: Kyle N. Hearn, Trent D. Ashton, Rameshwor Acharya, Zikai Feng, Nuri Gueven, Frederick M. Pfeffer
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
Buchwald–Hartwig
scriptaid
histone deacetylase
HDAC
1,8-naphthalimide
fluorescence
Online Access:https://www.mdpi.com/2073-4409/10/6/1505

Internet

https://www.mdpi.com/2073-4409/10/6/1505

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