Emergence of non-canonical parvalbumin-containing interneurons in hippocampus of a murine model of type I lissencephaly

Emergence of non-canonical parvalbumin-containing interneurons in hippocampus of a murine model of type I lissencephaly

Type I lissencephaly is a neuronal migration disorder caused by haploinsuffiency of the PAFAH1B1 (mouse: Pafah1b1) gene and is characterized by brain malformation, developmental delays, and epilepsy. Here, we investigate the impact of Pafah1b1 mutation on the cellular migration, morphophysiology, mi...

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Bibliographic Details
Main Authors: Tyler G Ekins, Vivek Mahadevan, Yajun Zhang, James A D'Amour, Gülcan Akgül, Timothy J Petros, Chris J McBain
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
lissencephaly
hippocampus
parvalbumin
fast-spiking
migration
epilepsy
Online Access:https://elifesciences.org/articles/62373

Internet

https://elifesciences.org/articles/62373

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