Newt cells secrete extracellular vesicles with therapeutic bioactivity in mammalian cardiomyocytes

Newt cells secrete extracellular vesicles with therapeutic bioactivity in mammalian cardiomyocytes

Newts can regenerate amputated limbs and cardiac tissue, unlike mammals which lack broad regenerative capacity. Several signaling pathways involved in cell proliferation, differentiation and survival during newt tissue regeneration have been elucidated, however the factors that coordinate signaling...

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Bibliographic Details
Main Authors: Ryan C. Middleton, Russell G. Rogers, Geoffrey De Couto, Eleni Tseliou, Kristin Luther, Ronald Holewinski, Daniel Soetkamp, Jennifer E. Van Eyk, Travis J. Antes, Eduardo Marbán
Format: Article
Language:English
Published: Taylor & Francis Group 2018-12-01
Series:Journal of Extracellular Vesicles
Subjects:
Exosomes
extracellular vesicles
newt
Urodele amphibians
apoptosis
cytoprotection
PI3K/AKT pathway
cardiomyocytes
tissue regeneration
Online Access:http://dx.doi.org/10.1080/20013078.2018.1456888

Internet

http://dx.doi.org/10.1080/20013078.2018.1456888

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