Asiaticoside Attenuates Cell Growth Inhibition and Apoptosis Induced by Aβ1-42 via Inhibiting the TLR4/NF-κB Signaling Pathway in Human Brain Microvascular Endothelial Cells

Asiaticoside Attenuates Cell Growth Inhibition and Apoptosis Induced by Aβ1-42 via Inhibiting the TLR4/NF-κB Signaling Pathway in Human Brain Microvascular Endothelial Cells

Alzheimer’s disease (AD) is a very common progressive neurodegenerative disorder with the highest incidence in the world. Dysfunction of the blood–brain barrier (BBB) may be responsible for the pathogenesis and pathology of AD for abnormally transporting amyloid-β (Aβ, the main component of the seni...

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Bibliographic Details
Main Authors: Daqiang Song, Xian Jiang, Yiliu Liu, Yuhong Sun, Shousong Cao, Zhuo Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer’s disease
asiaticoside
human brain microvascular endothelial cells (hBMECs)
Aβ1-42
TLR4
NF-κB
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00028/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00028/full

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