Wnt2b attenuates HSCs activation and liver fibrosis through negative regulating TLR4 signaling

Abstract The Wingless-type MMTV integration site family member 2b (Wnt2b) has been found to be a principal mediator of liver development and regeneration. However, the significance of Wnt2b in the pathogenesis of fibrosis-related liver diseases remains undefined. Here, we report that Wnt2b was highl...

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Bibliographic Details
Main Authors: Yi Yuan, Qiuju Han, Siyu Li, Zhigang Tian, Jian Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-04374-5