Computer-Aided Rational Engineering of Signal Sensitivity of Quorum Sensing Protein LuxR in a Whole-Cell Biosensor

Computer-Aided Rational Engineering of Signal Sensitivity of Quorum Sensing Protein LuxR in a Whole-Cell Biosensor

LuxR, a bacterial quorum sensing-related transcription factor that responds to the signaling molecule 3-oxo-hexanoyl-homoserine lactone (3OC6-HSL). In this study, we employed molecular dynamics simulation and the Molecular Mechanics Generalized Born Surface Area (MM-GB/SA) method to rationally ident...

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Bibliographic Details
Main Authors: Jinyu Li, Ruicun Liu, Yulu Chen, Shuxia Liu, Cheng Chen, Tuoyu Liu, Shan Yang, Yingtan Zhuang, Ruifu Yang, Yujun Cui, Yajun Song, Tao Wang, Yue Teng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
LuxR
rational protein engineering
signal sensitivity
quorum sensing
gene circuit
biosensor
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.729350/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.729350/full

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