Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson’s disease and other neurological disorders

Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson’s disease and other neurological disorders

Abstract Background Parkinson’s disease (PD) is the second most common neurodegenerative disorder. PD associated human UCHL1 (Ubiquitin C-terminal hydrolase L1) gene belongs to the family of deubiquitinases and is known to be highly expressed in neurons (1–2% in soluble form). Several functions of U...

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Bibliographic Details
Main Authors: Muhammad Saqib Nawaz, Razia Asghar, Nashaiman Pervaiz, Shahid Ali, Irfan Hussain, Peiqi Xing, Yiming Bao, Amir Ali Abbasi
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Evolutionary Biology
Subjects:
UCHL1
Epistasis
Neurodegenerative diseases
Parkinson’s disease
SNCA
Online Access:http://link.springer.com/article/10.1186/s12862-020-01684-7

Internet

http://link.springer.com/article/10.1186/s12862-020-01684-7

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