Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson’s disease and other neurological disorders
Abstract Background Parkinson’s disease (PD) is the second most common neurodegenerative disorder. PD associated human UCHL1 (Ubiquitin C-terminal hydrolase L1) gene belongs to the family of deubiquitinases and is known to be highly expressed in neurons (1–2% in soluble form). Several functions of U...
Main Authors: | Muhammad Saqib Nawaz, Razia Asghar, Nashaiman Pervaiz, Shahid Ali, Irfan Hussain, Peiqi Xing, Yiming Bao, Amir Ali Abbasi |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-10-01
|
Series: | BMC Evolutionary Biology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12862-020-01684-7 |
Similar Items
-
Molecular Characterization and Expression Profiles of Sp-uchl3 and Sp-uchl5 during Gonad Development of Scylla paramamosain
by: Kunhuang Han, et al.
Published: (2018-01-01) -
In silico analysis of hypermethylation in CpGislands of UCHL1 gene’s promoter in nasopharyngeal carcinoma
by: Lao Duc Thuan, et al.
Published: (2018-08-01) -
Lessons on the Sigma-1 Receptor in TNBS-Induced Rat Colitis: Modulation of the UCHL-1, IL-6 Pathway
by: Nikoletta Almási, et al.
Published: (2020-06-01) -
The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation
by: Yuting Gu, et al.
Published: (2018-10-01) -
Association of S18Y isomer in UCHL1 gene polymorphism with age-related cataract pathogenesis
by: Shuai-Jie Li, et al.
Published: (2019-10-01)