Glycogen synthase kinase-3 inhibition sensitizes human induced pluripotent stem cells to thiol-containing antioxidants induced apoptosis

Glycogen synthase kinase-3 inhibition sensitizes human induced pluripotent stem cells to thiol-containing antioxidants induced apoptosis

Inhibition of glycogen synthase kinase 3 (GSK3) is an extensively used strategy to activate Wnt pathway for pluripotent stem cell (PSC) differentiation. However, the effects of such inhibition on PSCs, besides upregulating the Wnt pathway, have rarely been investigated despite that GSK3 is broadly i...

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Bibliographic Details
Main Authors: Chengyi Tu, Robert Xu, Meghana Koleti, Janet Zoldan
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Stem Cell Research
Subjects:
Glycogen synthase kinase-3
Antioxidants
N-acetylcysteine
Beta-mercaptoethanol
Induced pluripotent stem cells
Apoptosis
Mammalian target of rapamycin
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506117301435

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http://www.sciencedirect.com/science/article/pii/S1873506117301435

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