Protein kinases PknA and PknB independently and coordinately regulate essential Mycobacterium tuberculosis physiologies and antimicrobial susceptibility.

Protein kinases PknA and PknB independently and coordinately regulate essential Mycobacterium tuberculosis physiologies and antimicrobial susceptibility.

The Mycobacterium tuberculosis Ser/Thr protein kinases PknA and PknB are essential for growth and have been proposed as possible drug targets. We used a titratable conditional depletion system to investigate the functions of these kinases. Depletion of PknA or PknB or both kinases resulted in growth...

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Bibliographic Details
Main Authors: Jumei Zeng, John Platig, Tan-Yun Cheng, Saima Ahmed, Yara Skaf, Lakshmi-Prasad Potluri, Daniel Schwartz, Hanno Steen, D Branch Moody, Robert N Husson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008452

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https://doi.org/10.1371/journal.ppat.1008452

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