Prophages and Growth Dynamics Confound Experimental Results with Antibiotic-Tolerant Persister Cells

Bacterial persisters are phenotypic variants that survive antibiotic treatment in a dormant state and can be formed by multiple pathways. We recently proposed that the second messenger (p)ppGpp drives Escherichia coli persister formation through protease Lon and activation of toxin-antitoxin (TA) mo...

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Bibliographic Details
Main Authors: Alexander Harms, Cinzia Fino, Michael A. Sørensen, Szabolcs Semsey, Kenn Gerdes, Joerg Vogel
Format: Article
Language:English
Published: American Society for Microbiology 2017-12-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/8/6/e01964-17