A Read/Write Mechanism Connects p300 Bromodomain Function to H2A.Z Acetylation

A Read/Write Mechanism Connects p300 Bromodomain Function to H2A.Z Acetylation

Summary: Acetylation of the histone variant H2A.Z (H2A.Zac) occurs at active regulatory regions associated with gene expression. Although the Tip60 complex is proposed to acetylate H2A.Z, functional studies suggest additional enzymes are involved. Here, we show that p300 acetylates H2A.Z at multiple...

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Bibliographic Details
Main Authors: Yolanda Colino-Sanguino, Evan M. Cornett, David Moulder, Grady C. Smith, Joel Hrit, Eric Cordeiro-Spinetti, Robert M. Vaughan, Krzysztof Krajewski, Scott B. Rothbart, Susan J. Clark, Fátima Valdés-Mora
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219304341

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http://www.sciencedirect.com/science/article/pii/S2589004219304341

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