Evidence for transcriptional factor dysregulation in the dorsal raphe nucleus of patients with major depressive disorder

Evidence for transcriptional factor dysregulation in the dorsal raphe nucleus of patients with major depressive disorder

Extensive evidence implicates dysfunction in serotonin (5-HT) signaling in the etiology of major depressive disorder (MDD). Dorsal raphe nucleus (DR) is a major source of serotonin in the brain, and previous studies have reported within it alterations in 5-HT-related gene expression, protein levels...

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Bibliographic Details
Main Authors: Ilan A Kerman, René eBernard, William eBunney, Edward eJones, Alan F Schatzberg, Richard eMyers, Jack eBarchas, Huda eAkil, Stanley eWatson, Robert eThompson
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-10-01
Series:Frontiers in Neuroscience
Subjects:
Depression
Gene Expression
Laser Capture Microdissection
Serotonin
Microarray
Real-Time PCR
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00135/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00135/full

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