Chemically homogenous compounds with antagonistic properties at all α1-adrenoceptor subtypes but not β1-adrenoceptor attenuate adrenaline-induced arrhythmia in rats

Chemically homogenous compounds with antagonistic properties at all α1-adrenoceptor subtypes but not β1-adrenoceptor attenuate adrenaline-induced arrhythmia in rats

Studies proved that among all α1-adrenoceptors, cardiac myocytes functionally express only α1A- and α1B-subtype. Scientists indicated that α1A-subtype blockade might be beneficial in restoring normal heart rhythm. Therefore, we aimed to determine the role of α1-adrenoceptors subtypes (i.e. α1A and α...

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Main Authors: Karolina Pytka, Klaudia Lustyk, Elżbieta Żmudzka, Magdalena Kotańska, Agata Siwek, Małgorzata Zygmunt, Agnieszka Dziedziczak, Joanna Śniecikowska, Adrian Olczyk, Adam Gałuszka, Jarosław Śmieja, Anna Maria Waszkielewicz, Henryk Marona, Barbara Filipek, Jacek Sapa, Szczepan Mogilski
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Pharmacology
Subjects:
arrhythmia
Hypotensive
Antiarrhythmic agents
α1A-adrenoceptor antagonist
2-methoxyphenylpiperazine
α1-adrenolytics
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00229/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00229/full

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