Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model

Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model

Objectives: Adjunctive host-directed therapy is emerging as a new potential approach to improve the outcome of conventional antimicrobial treatment for tuberculosis (TB). We tested the ability of a phosphodiesterase-4 inhibitor (PDE4i) CC-11050, co-administered with the first-line anti-TB drug isoni...

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Bibliographic Details
Main Authors: Selvakumar Subbian, Liana Tsenova, Jennifer Holloway, Blas Peixoto, Paul O'Brien, Véronique Dartois, Vikram Khetani, Jerome B. Zeldis, Gilla Kaplan
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:EBioMedicine
Subjects:
Pulmonary tuberculosis
Immune modulation
Phosphodiesterase inhibitor
Lung fibrosis
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416300111

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http://www.sciencedirect.com/science/article/pii/S2352396416300111

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