Cognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF biomarker profile

Cognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF biomarker profile

Abstract Background Understanding the changes that occur in the transitional stage between absent and overt amyloid-β (Aβ) pathology within the Alzheimer’s continuum is crucial to develop therapeutic and preventive strategies. The objective of this study is to test whether cognitively unimpaired ind...

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Main Authors: Marta Milà-Alomà, Mahnaz Shekari, Gemma Salvadó, Juan Domingo Gispert, Eider M. Arenaza-Urquijo, Grégory Operto, Carles Falcon, Natalia Vilor-Tejedor, Oriol Grau-Rivera, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, José Maria González-de-Echávarri, Carolina Minguillon, Karine Fauria, Aida Niñerola-Baizán, Andrés Perissinotti, Maryline Simon, Gwendlyn Kollmorgen, Henrik Zetterberg, Kaj Blennow, Marc Suárez-Calvet, José Luis Molinuevo, for the ALFA study
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Alzheimer’s Research & Therapy
Subjects:
Preclinical
Alzheimer’s disease
CSF
Biomarkers
Subthreshold
Cognitively unimpaired
Online Access:https://doi.org/10.1186/s13195-021-00863-y

Internet

https://doi.org/10.1186/s13195-021-00863-y

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