Identification of TCERG1 as a new genetic modulator of TDP-43 production in Drosophila

Identification of TCERG1 as a new genetic modulator of TDP-43 production in Drosophila

Abstract TAR DNA-binding protein-43 (TDP-43) is a ubiquitously expressed DNA-/RNA-binding protein that has been linked to numerous aspects of the mRNA life cycle. Similar to many RNA-binding proteins, TDP-43 expression is tightly regulated through an autoregulatory negative feedback loop. Cell funct...

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Bibliographic Details
Main Authors: Marine Pons, Silvia Prieto, Laetitia Miguel, Thierry Frebourg, Dominique Campion, Carles Suñé, Magalie Lecourtois
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Acta Neuropathologica Communications
Subjects:
TDP-43
Autoregulation
ALS
FTLD
TCERG1
Drosophila
Online Access:http://link.springer.com/article/10.1186/s40478-018-0639-5

Internet

http://link.springer.com/article/10.1186/s40478-018-0639-5

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