Identification of TCERG1 as a new genetic modulator of TDP-43 production in Drosophila
Abstract TAR DNA-binding protein-43 (TDP-43) is a ubiquitously expressed DNA-/RNA-binding protein that has been linked to numerous aspects of the mRNA life cycle. Similar to many RNA-binding proteins, TDP-43 expression is tightly regulated through an autoregulatory negative feedback loop. Cell funct...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2018-12-01
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Series: | Acta Neuropathologica Communications |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40478-018-0639-5 |