Identification of TCERG1 as a new genetic modulator of TDP-43 production in Drosophila
Abstract TAR DNA-binding protein-43 (TDP-43) is a ubiquitously expressed DNA-/RNA-binding protein that has been linked to numerous aspects of the mRNA life cycle. Similar to many RNA-binding proteins, TDP-43 expression is tightly regulated through an autoregulatory negative feedback loop. Cell funct...
Main Authors: | Marine Pons, Silvia Prieto, Laetitia Miguel, Thierry Frebourg, Dominique Campion, Carles Suñé, Magalie Lecourtois |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2018-12-01
|
Series: | Acta Neuropathologica Communications |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40478-018-0639-5 |
Similar Items
-
Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies
by: Laetitia Miguel, et al.
Published: (2011-02-01) -
A novel Drosophila model of TDP-43 proteinopathies: N-terminal sequences combined with the Q/N domain induce protein functional loss and locomotion defects
by: Simona Langellotti, et al.
Published: (2016-06-01) -
Inter-Species Differences in Regulation of the Progranulin–Sortilin Axis in TDP-43 Cell Models of Neurodegeneration
by: Valentina Gumina, et al.
Published: (2019-11-01) -
Pathway from TDP-43-Related Pathology to Neuronal Dysfunction in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration
by: Yuichi Riku, et al.
Published: (2021-04-01) -
The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons
by: Daiyu Honda, et al.
Published: (2014-01-01)