Increased Expression of the EZH2 Polycomb Group Gene in BMI-1-Positive Neoplastic Cells during Bronchial Carcinogenesis

Increased Expression of the EZH2 Polycomb Group Gene in BMI-1-Positive Neoplastic Cells during Bronchial Carcinogenesis

Polycomb group (PcG) genes are responsible for maintenance of cellular identity and contribute to regulation of the cell cycle. Recent studies have identified several PcG genes as oncogenes, and a role for PcG proteins in human oncogenesis is suspected. We investigated the expression of BMI-1 and E...

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Bibliographic Details
Main Authors: Roderick H.J. Breuer, Peter J.F. Snijders, Egbert F. Smit, Thomas G. Sutedja, Richard G.A.B. Sewalt, Arie P. Otte, Folkert J. van Kemenade, Pieter E. Postmus, Chris J.L.M. Meijer, Frank M. Raaphorst
Format: Article
Language:English
Published: Elsevier 2004-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Premalignant lesions
BMI-1
EZH2
polycomb genes
lung carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558604800058

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http://www.sciencedirect.com/science/article/pii/S1476558604800058

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