Time-dependent effects of histone deacetylase inhibition in sepsis-associated acute kidney injury

Time-dependent effects of histone deacetylase inhibition in sepsis-associated acute kidney injury

Abstract Background Sepsis, a dysregulated host response to infection with results in organ dysfunction, has been a major challenge to the development of effective therapeutics. Sepsis-associated acute kidney injury (S-AKI) results in a 3–5-fold increase in the risk of hospital mortality compared to...

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Bibliographic Details
Main Authors: Xiaoyan Wen, Shengnan Li, Alicia Frank, Xiukai Chen, David Emlet, Neil A. Hukriede, John A. Kellum
Format: Article
Language:English
Published: SpringerOpen 2020-02-01
Series:Intensive Care Medicine Experimental
Subjects:
Acute kidney injury
Renal tissue fibrosis
Sepsis
Histone deacetylase inhibitors
Online Access:https://doi.org/10.1186/s40635-020-0297-3

Internet

https://doi.org/10.1186/s40635-020-0297-3

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