Coenzyme Q10 or Creatine Counteract Pravastatin-Induced Liver Redox Changes in Hypercholesterolemic Mice

Coenzyme Q10 or Creatine Counteract Pravastatin-Induced Liver Redox Changes in Hypercholesterolemic Mice

Statins are the preferred therapy to treat hypercholesterolemia. Their main action consists of inhibiting the cholesterol biosynthesis pathway. Previous studies report mitochondrial oxidative stress and membrane permeability transition (MPT) of several experimental models submitted to diverse statin...

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Bibliographic Details
Main Authors: Ana C. Marques, Estela N. B. Busanello, Diogo N. de Oliveira, Rodrigo R. Catharino, Helena C. F. Oliveira, Anibal E. Vercesi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Pharmacology
Subjects:
pravastatin
LDL receptor knockout mice
mitochondria
reactive oxygen species
coenzyme Q10
creatine
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00685/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00685/full

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