Initial seronegative immune-mediated necrotising myopathy with subsequent anti-HMGCR antibody development and response to rituximab: case report

Initial seronegative immune-mediated necrotising myopathy with subsequent anti-HMGCR antibody development and response to rituximab: case report

Abstract Background Immune-mediated necrotising myopathy (IMNM) is characterised by severe muscle weakness and necrosis with a paucity of inflammation on muscle biopsy. Around 60% of cases are associated with antibodies to the signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-coenzyme...

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Bibliographic Details
Main Authors: Rhys Thomas, Su-Ann Yeoh, Rupert Berkeley, Andrew Woods, Mike Stevens, Silvia Marino, Aleksandar Radunovic
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Rheumatology
Subjects:
Anti-HMGCR
Immune-mediated necrotizing myopathy
Myalgia
Case report
Online Access:http://link.springer.com/article/10.1186/s41927-020-00128-5

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http://link.springer.com/article/10.1186/s41927-020-00128-5

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