Role of hypoxia and growth and differentiation factor-5 on differentiation of human mesenchymal stem cells towards intervertebral nucleus pulposus-like cells

Role of hypoxia and growth and differentiation factor-5 on differentiation of human mesenchymal stem cells towards intervertebral nucleus pulposus-like cells

There is evidence that mesenchymal stem cells (MSCs) can differentiate towards an intervertebral disc (IVD)-like phenotype. We compared the standard chondrogenic protocol using transforming growth factor beta-1 (TGFß) to the effects of hypoxia, growth and differentiation factor-5 (GDF5), and cocultu...

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Bibliographic Details
Main Authors: JV Stoyanov, B Gantenbein-Ritter, A Bertolo, N Aebli, M Baur, M Alini, S Grad
Format: Article
Language:English
Published: AO Research Institute Davos 2011-06-01
Series:European Cells & Materials
Subjects:
Stem cells
chondrogenesis
tissue engineering
intervertebral disc
nucleus pulposus
signalling molecules
growth factors
Online Access:http://www.ecmjournal.org/journal/papers/vol021/pdf/v021a40.pdf

Internet

http://www.ecmjournal.org/journal/papers/vol021/pdf/v021a40.pdf

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