MicroRNA Modification of Coxsackievirus B3 Decreases Its Toxicity, while Retaining Oncolytic Potency against Lung Cancer

MicroRNA Modification of Coxsackievirus B3 Decreases Its Toxicity, while Retaining Oncolytic Potency against Lung Cancer

Show other versions (1)

We recently discovered that coxsackievirus B3 (CVB3) is a potent oncolytic virus against KRAS mutant lung adenocarcinoma. Nevertheless, the evident toxicity restricts the use of wild-type (WT)-CVB3 for cancer therapy. The current study aims to engineer the CVB3 to decrease its toxicity and to extend...

Full description

Bibliographic Details
Main Authors: Huitao Liu, Yuan Chao Xue, Haoyu Deng, Yasir Mohamud, Chen Seng Ng, Axel Chu, Chinten James Lim, William W. Lockwood, William W.G. Jia, Honglin Luo
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Molecular Therapy: Oncolytics
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520300085

Internet

http://www.sciencedirect.com/science/article/pii/S2372770520300085

Similar Items