Neural stem cells from a mouse model of Rett syndrome are prone to senescence, show reduced capacity to cope with genotoxic stress, and are impaired in the differentiation process

Neural stem cells from a mouse model of Rett syndrome are prone to senescence, show reduced capacity to cope with genotoxic stress, and are impaired in the differentiation process

Rett syndrome: Mutation affects neural stem cells In Rett syndrome, neural stem cells lose some of their “stem cell like” properties, impairing brain functions. Patients with this rare neurological condition, almost exclusively girls, show impaired movement and speech beginning at 6–18 months of age...

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Bibliographic Details
Main Authors: Nicola Alessio, Francesco Riccitiello, Tiziana Squillaro, Stefania Capasso, Stefania Del Gaudio, Giovanni Di Bernardo, Marilena Cipollaro, Mariarosa A. B. Melone, Gianfranco Peluso, Umberto Galderisi
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-017-0005-x

Internet

https://doi.org/10.1038/s12276-017-0005-x

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