Loss of Niemann Pick type C proteins 1 and 2 greatly enhances HIV infectivity and is associated with accumulation of HIV Gag and cholesterol in late endosomes/lysosomes

Loss of Niemann Pick type C proteins 1 and 2 greatly enhances HIV infectivity and is associated with accumulation of HIV Gag and cholesterol in late endosomes/lysosomes

<p>Abstract</p> <p>Background</p> <p>Cholesterol pathways play an important role at multiple stages during the HIV-1 infection cycle. Here, we investigated the role of cholesterol trafficking in HIV-1 replication utilizing Niemann-Pick Type C disease (NPCD) cells as a m...

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Bibliographic Details
Main Authors: Coleman Ebony M, Walker Tiffany N, Hildreth James EK
Format: Article
Language:English
Published: BMC 2012-01-01
Series:Virology Journal
Online Access:http://www.virologyj.com/content/9/1/31

Internet

http://www.virologyj.com/content/9/1/31

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