Synthesis and Biological Evaluation of New Pyridone-Annelated Isoindigos as Anti-Proliferative Agents

Synthesis and Biological Evaluation of New Pyridone-Annelated Isoindigos as Anti-Proliferative Agents

A selected set of substituted pyridone-annelated isoindigos 3a–f has been synthesized via interaction of 5- and 6-substituted oxindoles 2a–f with 6-ethyl-1,2,9-trioxopyrrolo[3,2-f]quinoline-8-carboxylic acid (1) in acetic acid at reflux. Among these isoindigos, the 5'-chloro and 5'-bromo d...

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Bibliographic Details
Main Authors: Ayman M. Saleh, Randa M. Al-As'ad, Mustafa M. El-Abadelah, Salim S. Sabri, Jalal A. Zahra, Ahmed S. Alaskar, Ahmad Aljada
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:Molecules
Subjects:
pyridone-annelated isoindigos
5'-halogeno derivatives
isoindigo
anticancer compounds
antiproliferative activity
apoptosis
K562 cells
THP-1 cells
HepG2 cells
MCF-7 cells
Caco-2 cells
HEK-293 cells
L-929 cells
MTT assay
Online Access:http://www.mdpi.com/1420-3049/19/9/13076

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http://www.mdpi.com/1420-3049/19/9/13076

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