Profiling diverse sequence tandem repeats in colorectal cancer reveals co-occurrence of microsatellite and chromosomal instability involving Chromosome 8

Profiling diverse sequence tandem repeats in colorectal cancer reveals co-occurrence of microsatellite and chromosomal instability involving Chromosome 8

Abstract We developed a sensitive sequencing approach that simultaneously profiles microsatellite instability, chromosomal instability, and subclonal structure in cancer. We assessed diverse repeat motifs across 225 microsatellites on colorectal carcinomas. Our study identified elevated alterations...

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Bibliographic Details
Main Authors: GiWon Shin, Stephanie U. Greer, Erik Hopmans, Susan M. Grimes, HoJoon Lee, Lan Zhao, Laura Miotke, Carlos Suarez, Alison F. Almeda, Sigurdis Haraldsdottir, Hanlee P. Ji
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Genome Medicine
Subjects:
Microsatellite instability
Sequence tandem repeats
Chromosomal instability
Colorectal cancer
DNA mismatch repair
Online Access:https://doi.org/10.1186/s13073-021-00958-z

Internet

https://doi.org/10.1186/s13073-021-00958-z

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