Development of a single-chain fragment variable fused-mutant HALT-1 recombinant immunotoxin against G12V mutated KRAS colorectal cancer cells

Development of a single-chain fragment variable fused-mutant HALT-1 recombinant immunotoxin against G12V mutated KRAS colorectal cancer cells

Background KRAS oncogenes harboring codon G12 and G13 substitutions are considered gatekeeper mutations which drive oncogenesis in many cancers. To date, there are still no target-specific vaccines or drugs available against this genotype, thus reinforcing the need towards the development of targete...

Full description

Bibliographic Details
Main Authors: Michelle Yee Mun Teo, Jeremy Jeack Ceen Ng, Jung Yin Fong, Jung Shan Hwang, Adelene Ai-Lian Song, Renee Lay Hong Lim, Lionel Lian Aun In
Format: Article
Language:English
Published: PeerJ Inc. 2021-04-01
Series:PeerJ
Subjects:
KRAS
scfv
Immunotoxin
HALT-1
Hydra
Phagemid
Online Access:https://peerj.com/articles/11063.pdf

Internet

https://peerj.com/articles/11063.pdf

Similar Items