The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration

The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration

Induction of mitochondrial oxidative respiration is required for stem cell differentiation, but the mechanisms underlying this process are poorly understood. Here, the authors report that Stat3 promotes muscle stem cell differentiation by stimulating mitochondrial respiration via Fam3a.

Bibliographic Details
Main Authors: David Sala, Thomas J. Cunningham, Michael J. Stec, Usue Etxaniz, Chiara Nicoletti, Alessandra Dall’Agnese, Pier Lorenzo Puri, Gregg Duester, Lucia Latella, Alessandra Sacco
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09746-1

Internet

https://doi.org/10.1038/s41467-019-09746-1

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