The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor

The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor

Trace amine-associated receptors (TAARs) belong to the class A G-protein-coupled receptors (GPCR) and are evolutionary related to aminergic receptors. TAARs have been identified to mediate effects of trace amines. TAAR1 signaling is mainly mediated via activation of the Gs/adenylyl cyclase pathway....

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Bibliographic Details
Main Authors: Julia Bräunig, Juliane Dinter, Carolin S. Höfig, Sarah Paisdzior, Michal Szczepek, Patrick Scheerer, Mark Rosowski, Jens Mittag, Gunnar Kleinau, Heike Biebermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Pharmacology
Subjects:
trace amine-associated receptor 1 (TAAR1)
serotonin receptor 1b (5-HT1b)
3-T1AM
signal transduction
biased signaling
trace amines
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00222/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00222/full

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